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Efficacy of vorinostat in a murine model of polycythemia vera

The discovery of the JAK2V617F mutation in most patients with Ph-negative myeloproliferative neoplasms has led to the development of JAK2 kinase inhibitors. However, JAK2 inhibitor therapy has shown limited efficacy and dose-limiting hematopoietic toxicities in clinical trials. In the present study,...

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Autores principales: Akada, Hajime, Akada, Saeko, Gajra, Ajeet, Bair, Alicia, Graziano, Stephen, Hutchison, Robert E., Mohi, Golam
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335382/
https://ncbi.nlm.nih.gov/pubmed/22408262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-02-336743
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