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Design, Synthesis, and Initial Biological Evaluation of a Steroidal Anti-estrogen–Doxorubicin Bioconjugate for Targeting Estrogen Receptor-Positive Breast Cancer Cells
As part of our program to develop breast cancer specific therapeutic agents we have synthesized a conjugate-agent that is a conjugate of the steroidal anti-estrogen and the potent cytotoxin doxorubicin. In this effort we employed a modular assembly approach to prepare a novel 11β-substituted steroid...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3335367/ https://ncbi.nlm.nih.gov/pubmed/22404783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc200645n |
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