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Design, Synthesis, and Initial Biological Evaluation of a Steroidal Anti-estrogen–Doxorubicin Bioconjugate for Targeting Estrogen Receptor-Positive Breast Cancer Cells

As part of our program to develop breast cancer specific therapeutic agents we have synthesized a conjugate-agent that is a conjugate of the steroidal anti-estrogen and the potent cytotoxin doxorubicin. In this effort we employed a modular assembly approach to prepare a novel 11β-substituted steroid...

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Hlavní autoři: Dao, Kinh-Luan, Sawant, Rupa R., Hendricks, J. Adam, Ronga, Victoria, Torchilin, Vladimir P., Hanson, Robert N.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335367/
https://ncbi.nlm.nih.gov/pubmed/22404783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc200645n
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