Pleiotropy of Glycogen Synthase Kinase-3 Inhibition by CHIR99021 Promotes Self-Renewal of Embryonic Stem Cells from Refractory Mouse Strains

BACKGROUND: Inhibition of glycogen synthase kinase-3 (GSK-3) improves the efficiency of embryonic stem (ES) cell derivation from various strains of mice and rats, as well as dramatically promotes ES cell self-renewal potential. β-catenin has been reported to be involved in the maintenance of self-re...

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Detalhes bibliográficos
Main Authors: Ye, Shoudong, Tan, Li, Yang, Rongqing, Fang, Bo, Qu, Su, Schulze, Eric N., Song, Houyan, Ying, Qilong, Li, Ping
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335080/
https://ncbi.nlm.nih.gov/pubmed/22540008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035892
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