Sprouty1 inhibits angiogenesis in association with up-regulation of p21 and p27

Sprouty1 (Spry1) is a conserved antagonist of FGF signaling. The goal of this study was to further explore the downstream mechanisms governing Spry1 inhibition of endothelial cell proliferation. Up-regulation of Spry1 in HUVECs inhibited tube formation on Matrigel (n = 6, P < 0.001). This was ass...

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Bibliografiske detaljer
Main Authors: Lee, Sangjin, Nguyen, Tri M. Bui, Kovalenko, Dmitry, Adhikari, Neeta, Grindle, Suzanne, Polster, Sean P., Friesel, Robert, Ramakrishnan, Sundaram, Hall, Jennifer L.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3334870/
https://ncbi.nlm.nih.gov/pubmed/20054616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11010-009-0359-z
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