The synthetic Tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis

INTRODUCTION: Angiopoietin-1 (Angpt1), the natural agonist ligand for the endothelial Tie2 receptor, is a non-redundant endothelial survival and vascular stabilization factor that reduces endothelial permeability and inhibits leukocyte-endothelium interactions. Here we evaluate the efficacy of a nov...

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Autori principali: Kümpers, Philipp, Gueler, Faikah, David, Sascha, Van Slyke, Paul, Dumont, Daniel J, Park, Joon-Keun, Bockmeyer, Clemens L, Parikh, Samir M, Pavenstädt, Hermann, Haller, Hermann, Shushakova, Nelli
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2011
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3334812/
https://ncbi.nlm.nih.gov/pubmed/22040774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc10523
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