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Effects of a synthetic PEG-ylated Tie-2 agonist peptide on endotoxemic lung injury and mortality

A synthetic 7-mer, HHHRHSF, was recently identified by screening a phage display library for binding to the Tie-2 receptor. A polyethylene-oxide clustered version of this peptide, termed vasculotide (VT), was reported to activate Tie-2 and promote angiogenesis in a mouse model of diabetic ulcer. We...

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Detalhes bibliográficos
Main Authors: David, Sascha, Ghosh, Chandra C., Kümpers, Philipp, Shushakova, Nelli, Van Slyke, Paul, Khankin, Eliyahu V., Karumanchi, S. Ananth, Dumont, Dan, Parikh, Samir M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3119126/
https://ncbi.nlm.nih.gov/pubmed/21421750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00459.2010
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