Human Longevity and Variation in GH/IGF-1/Insulin Signaling, DNA Damage Signaling and Repair and Pro/antioxidant Pathway Genes: Cross Sectional and Longitudinal Studies

Here we explore association with human longevity of common genetic variation in three major candidate pathways: GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidants by investigating 1273 tagging SNPs in 148 genes composing these pathways. In a case-control study of 1089 o...

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Autors principals: Soerensen, Mette, Dato, Serena, Tan, Qihua, Thinggaard, Mikael, Kleindorp, Rabea, Beekman, Marian, Jacobsen, Rune, Suchiman, H. Eka D., de Craen, Anton J.M., Westendorp, Rudi G.J., Schreiber, Stefan, Stevnsner, Tinna, Bohr, Vilhelm A., Slagboom, P. Eline, Nebel, Almut, Vaupel, James W., Christensen, Kaare, McGue, Matt, Christiansen, Lene
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3334439/
https://ncbi.nlm.nih.gov/pubmed/22406557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2012.02.010
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