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Ageing, autoimmunity and arthritis: Perturbations of TCR signal transduction pathways with ageing – a biochemical paradigm for the ageing immune system

It is widely accepted that cell-mediated immune functions decline with age, rendering an individual more susceptible to infection and possibly cancer, as well as to age-associated autoimmune diseases. The exact causes of T-cell functional decline are not known. One possible cause could be the develo...

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Autors principals: Fülöp, Tamàs, Larbi, Anis, Dupuis, Gilles, Pawelec, Graham
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2003
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC333419/
https://ncbi.nlm.nih.gov/pubmed/14680505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar1019
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