Human immunodeficiency virus-1 Tat activates NF-κB via physical interaction with IκB-α and p65

Nuclear factor (NF)-κB is a master regulator of pro-inflammatory genes and is upregulated in human immunodeficiency virus 1 (HIV-1) infection. Mechanisms underlying the NF-κB deregulation by HIV-1 are relevant for immune dysfunction in AIDS. We report that in single round HIV-1 infection, or single-...

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Hlavní autoři: Fiume, Giuseppe, Vecchio, Eleonora, De Laurentiis, Annamaria, Trimboli, Francesca, Palmieri, Camillo, Pisano, Antonio, Falcone, Cristina, Pontoriero, Marilena, Rossi, Annalisa, Scialdone, Annarita, Fasanella Masci, Francesca, Scala, Giuseppe, Quinto, Ileana
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
Molecular Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3333881/
https://ncbi.nlm.nih.gov/pubmed/22187158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1224
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