The association of Toll-like receptor 4 gene polymorphisms with the development of emphysema in Japanese subjects: a case control study

BACKGROUND: The principal role of Toll-like receptor 4 (TLR4) is the induction of immune responses to lipopolysaccharides. Previously, mice deficient in the TLR4 gene exhibited up-regulation of the NADPH oxidase system in the lungs. This resulted in increased oxidant generation and elastolytic activ...

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Hlavní autoři: Ito, Michiko, Hanaoka, Masayuki, Droma, Yunden, Kobayashi, Nobumitsu, Yasuo, Masanori, Kitaguchi, Yoshiaki, Horiuchi, Toshimichi, Ikegawa, Kayoko, Katsuyama, Yoshihiko, Kubo, Keishi, Ota, Masao
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3333474/
https://ncbi.nlm.nih.gov/pubmed/22251849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-0500-5-36
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