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Oligomerization propensity and flexibility of yeast frataxin studied by X-ray crystallography and small-angle X-ray scattering

Frataxin is a mitochondrial protein with a central role in iron homeostasis. Defects in frataxin function lead to Friedreich’s ataxia, a progressive neurodegenerative disease with childhood onset. The function of frataxin has been shown to be closely associated with its ability to form oligomeric sp...

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Bibliografske podrobnosti
Main Authors: Söderberg, Christopher AG, Shkumatov, Alexander V., Rajan, Sreekanth, Gakh, Oleksandr, Svergun, Dmitri I., Isaya, Grazia, Al-Karadaghi, Salam
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3332085/
https://ncbi.nlm.nih.gov/pubmed/22051511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.10.034
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