In vitro Phosphorylation of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase by Src Kinase

Focal adhesion kinase (FAK), a key regulator of cell adhesion and migration, is overexpressed in many types of cancer. The C-terminal focal adhesion targeting (FAT) domain of FAK is necessary for proper localization of FAK to focal adhesions and subsequent activation. Phosphorylation of Y926 in the...

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Hauptverfasser: Cable, Jennifer, Prutzman, Kirk, Gunawardena, Harsha P., Schaller, Michael D., Chen, Xian, Campbell, Sharon L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3332079/
https://ncbi.nlm.nih.gov/pubmed/22372511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300123a
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