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Solution Structure, Mechanism of Replication, and Optimization of an Unnatural Base Pair

As part of an ongoing effort to expand the genetic alphabet for in vitro and eventual in vivo applications, we have synthesized a wide variety of predominantly hydrophobic unnatural base pairs and evaluated their replication in DNA. Collectively, the results have led us to propose that these base pa...

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Main Authors: Malyshev, Denis A., Pfaff, Danielle A., Ippoliti, Shannon I., Hwang, Gil Tae, Dwyer, Tammy J., Romesberg, Floyd E.
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3332063/
https://ncbi.nlm.nih.gov/pubmed/20859962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201000959
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