Botch (NPG7) Promotes Neurogenesis by Antagonizing Notch

Regulation of self-renewal and differentiation of neural stem cells is still poorly understood. Here we investigate the role of a developmentally expressed protein, Botch, which blocks Notch, in neocortical development. Downregulation of Botch in vivo leads to cellular retention in the ventricular a...

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Detalhes bibliográficos
Main Authors: Chi, Zhikai, Zhang, Jianmin, Tokunaga, Akinori, Harraz, Maged M., Byrne, Sean T., Dolinko, Andrew, Xu, Jing, Blackshaw, Seth, Gaiano, Nicholas, Dawson, Ted M., Dawson, Valina L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3331935/
https://ncbi.nlm.nih.gov/pubmed/22445366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2012.02.011
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