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TiCl(4)-Promoted Tandem Carbonyl or Imine Addition and Friedel-Crafts Cyclization: Synthesis of Benzo-fused Oxabicyclooctanes and Nonanes

[Image: see text] A new and convenient synthesis of benzo-fused 8-oxabicyclo[3.2.1]octane and 9-oxabicyclo[4.2.1]nonane derivatives are described. The reaction involved a TiCl(4)-mediated tandem carbonyl or imine addition followed by a Friedel-Crafts cyclization to provide these functionalized deriv...

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Detalhes bibliográficos
Main Authors: Ghosh, Arun K., Martyr, Cuthbert D., Xu, Chun-Xiao
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3331910/
https://ncbi.nlm.nih.gov/pubmed/22475177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol300494q
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