Diabetes-Associated Common Genetic Variation and Its Association With GLP-1 Concentrations and Response to Exogenous GLP-1

The mechanisms by which common genetic variation predisposes to type 2 diabetes remain unclear. The disease-associated variants in TCF7L2 (rs7903146) and WFS1 (rs10010131) have been shown to affect response to exogenous glucagon-like peptide 1 (GLP-1), while variants in KCNQ1 (rs151290, rs2237892, a...

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Hlavní autoři: Smushkin, Galina, Sathananthan, Matheni, Sathananthan, Airani, Dalla Man, Chiara, Micheletto, Francesco, Zinsmeister, Alan R., Cobelli, Claudio, Vella, Adrian
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2012
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3331759/
https://ncbi.nlm.nih.gov/pubmed/22461567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1732
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