Lysophosphatidic acid and sphingosine-1-phosphate promote morphogenesis and block invasion of prostate cancer cells in three-dimensional organotypic models

Normal prostate and some malignant prostate cancer (PrCa) cell lines undergo acinar differentiation and form spheroids in three-dimensional (3-D) organotypic culture. Acini formed by PC-3 and PC-3M, less pronounced also in other PrCa cell lines, spontaneously undergo an invasive switch, leading to t...

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Main Authors: Härmä, V, Knuuttila, M, Virtanen, J, Mirtti, T, Kohonen, P, Kovanen, P, Happonen, A, Kaewphan, S, Ahonen, I, Kallioniemi, O, Grafström, R, Lötjönen, J, Nees, M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3330266/
https://ncbi.nlm.nih.gov/pubmed/21996742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.396
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