Association of genomic instability, and the methylation status of imprinted genes and mismatch-repair genes, with neural tube defects

We studied the genomic instability and methylation status of the mismatch-repair (MMR) genes hMLH1 and hMSH2, and the imprinted genes H19/IGF2, in fetuses with neural tube defects (NTDs) to explore the pathogenesis of the disease. Microsatellite instability (MSI) was observed in 23 of 50 NTD patient...

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Main Authors: Liu, Zhuo, Wang, Zhigang, Li, Yuanyuan, Ouyang, Shengrong, Chang, Huibo, Zhang, Ting, Zheng, Xiaoying, Wu, Jianxin
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3330220/
https://ncbi.nlm.nih.gov/pubmed/22234160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2011.242
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