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Comparative Molecular Dynamics Simulations of the Antimicrobial Peptide CM15 in Model Lipid Bilayers

We report altogether 3-μs molecular dynamics (MD) simulations of the antimicrobial peptide CM15 to systematically investigate its interaction with two model lipid bilayers, pure POPC and mixed POPG:POPC (1:2). Starting with either an α-helical or a random-coil conformation, CM15 is found to insert i...

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Detalhes bibliográficos
Main Authors: Wang, Yi, Schlamadinger, Diana E., Kim, Judy E., McCammon, J. Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329965/
https://ncbi.nlm.nih.gov/pubmed/22387432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2012.02.017
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