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The dynamic stress-induced “O-Glcnac-ome” highlights functions for O-GlcNAc in regulating DNA damage/repair and other cellular pathways

The modification of nuclear, mitochondrial, and cytoplasmic proteins by O-linked β-N-acetylglucosamine (O-GlcNAc) is a dynamic and essential post-translational modification of metazoans. Numerous forms of cellular injury lead to elevated levels of O-GlcNAc in both in vivo and in vitro models, and el...

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Detalhes bibliográficos
Main Authors: Zachara, Natasha E., Molina, Henrik, Wong, Ker Yi, Pandey, Akhilesh, Hart, Gerald W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329784/
https://ncbi.nlm.nih.gov/pubmed/20676906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00726-010-0695-z
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