Cardiac βARK1 inhibition prolongs survival and augments β blocker therapy in a mouse model of severe heart failure

Chronic human heart failure is characterized by abnormalities in β-adrenergic receptor (βAR) signaling, including increased levels of βAR kinase 1 (βARK1), which seems critical to the pathogenesis of the disease. To determine whether inhibition of βARK1 is sufficient to rescue a model of severe hear...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Harding, Victoria B., Jones, Larry R., Lefkowitz, Robert J., Koch, Walter J., Rockman, Howard A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33295/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11331748/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.091102398
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