Cardiac βARK1 inhibition prolongs survival and augments β blocker therapy in a mouse model of severe heart failure

Chronic human heart failure is characterized by abnormalities in β-adrenergic receptor (βAR) signaling, including increased levels of βAR kinase 1 (βARK1), which seems critical to the pathogenesis of the disease. To determine whether inhibition of βARK1 is sufficient to rescue a model of severe hear...

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Bibliographic Details
Main Authors: Harding, Victoria B., Jones, Larry R., Lefkowitz, Robert J., Koch, Walter J., Rockman, Howard A.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2001
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC33295/
https://ncbi.nlm.nih.gov/pubmed/11331748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.091102398
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