Conserved cysteine to serine mutation in tyrosinase is responsible for the classical albino mutation in laboratory mice.

Albinism, due to a lack of melanin pigment, is one of the oldest known mutations in mice. Tyrosinase (monophenol oxygenase, EC 1.14.18.1) is the first enzyme in the pathway for melanin synthesis, and the gene encoding this enzyme has been mapped to the mouse albino (c) locus. We have used mouse tyro...

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Bibliographic Details
Main Authors: Yokoyama, T, Silversides, D W, Waymire, K G, Kwon, B S, Takeuchi, T, Overbeek, P A
Format: Artigo
Language:Inglês
Published: 1990
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC332865/
https://ncbi.nlm.nih.gov/pubmed/2124349
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