The Q705K Polymorphism in NLRP3 Is a Gain-of-Function Alteration Leading to Excessive Interleukin-1β and IL-18 Production

BACKGROUND: The Q705K polymorphism in NLRP3 has been implicated in several chronic inflammatory diseases. In this study we determine the functional role of this commonly occurring polymorphism using an in-vitro system. PRINCIPAL FINDINGS: NLRP3-WT and NLRP3-Q705K were retrovirally transduced into th...

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Hoofdauteurs: Verma, Deepti, Särndahl, Eva, Andersson, Henrik, Eriksson, Per, Fredrikson, Mats, Jönsson, Jan-Ingvar, Lerm, Maria, Söderkvist, Peter
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2012
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328489/
https://ncbi.nlm.nih.gov/pubmed/22529966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034977
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