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Conformational States of a Bacterial α(2)-Macroglobulin Resemble Those of Human Complement C3
α(2) macroglobulins (α(2)Ms) are broad-spectrum protease inhibitors that play essential roles in the innate immune system of eukaryotic species. These large, multi-domain proteins are characterized by a broad-spectrum bait region and an internal thioester, which, upon cleavage, becomes covalently as...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3328433/ https://ncbi.nlm.nih.gov/pubmed/22530012 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035384 |
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