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Conformational States of a Bacterial α(2)-Macroglobulin Resemble Those of Human Complement C3

α(2) macroglobulins (α(2)Ms) are broad-spectrum protease inhibitors that play essential roles in the innate immune system of eukaryotic species. These large, multi-domain proteins are characterized by a broad-spectrum bait region and an internal thioester, which, upon cleavage, becomes covalently as...

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Библиографические подробности
Главные авторы: Neves, David, Estrozi, Leandro F., Job, Viviana, Gabel, Frank, Schoehn, Guy, Dessen, Andréa
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328433/
https://ncbi.nlm.nih.gov/pubmed/22530012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035384
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