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Molecular Requirements for Peroxisomal Targeting of Alanine-Glyoxylate Aminotransferase as an Essential Determinant in Primary Hyperoxaluria Type 1

Alanine-glyoxylate aminotransferase is a peroxisomal enzyme, of which various missense mutations lead to irreversible kidney damage via primary hyperoxaluria type 1, in part caused by improper peroxisomal targeting. To unravel the molecular mechanism of its recognition by the peroxisomal receptor Pe...

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Main Authors: Fodor, Krisztián, Wolf, Janina, Erdmann, Ralf, Schliebs, Wolfgang, Wilmanns, Matthias
格式: Artigo
語言:Inglês
出版: Public Library of Science 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328432/
https://ncbi.nlm.nih.gov/pubmed/22529745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001309
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