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Radiosensitization by the novel DNA intercalating agent vosaroxin
PURPOSE: Vosaroxin is a first in class naphthyridine analog structurally related to quinolone antibacterials, that intercalates DNA and inhibits topoisomerase II. Vosaroxin is not a P-glycoprotein receptor substrate and its activity is independent of p53, thus evading common drug resistance mechanis...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BioMed Central
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3328287/ https://ncbi.nlm.nih.gov/pubmed/22369205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1748-717X-7-26 |
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