WNT signaling increases proliferation and impairs differentiation of stem cells in the developing cerebellum

The WNT pathway plays multiple roles in neural development and is crucial for establishment of the embryonic cerebellum. In addition, WNT pathway mutations are associated with medulloblastoma, the most common malignant brain tumor in children. However, the cell types within the cerebellum that are r...

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Detalhes bibliográficos
Main Authors: Pei, Yanxin, Brun, Sonja N., Markant, Shirley L., Lento, William, Gibson, Paul, Taketo, Makoto M., Giovannini, Marco, Gilbertson, Richard J., Wechsler-Reya, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: Company of Biologists 2012
Assuntos:
Development and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328175/
https://ncbi.nlm.nih.gov/pubmed/22461560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.050104
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