Deficits in axonal transport in hippocampal-based circuitry and the visual pathway in APP knock-out animals witnessed by manganese enhanced MRI

Mounting evidence implicates axonal transport defects, typified by the presence of axonal varicosities with aberrant accumulations of cargo, as an early event in Alzheimer’s disease (AD) pathogenesis. Work identifying amyloid precursor protein (APP) as a vesicular motor receptor for anterograde axon...

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Bibliographic Details
Main Authors: Gallagher, Joseph J., Zhang, Xiaowei, Ziomek, Greg, Jacobs, Russell E., Bearer, Elaine L.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328142/
https://ncbi.nlm.nih.gov/pubmed/22500926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroimage.2012.01.132
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