A Systems Biology Approach to Characterize the Regulatory Networks Leading to Trabectedin Resistance in an In Vitro Model of Myxoid Liposarcoma

Trabectedin, a new antitumor compound originally derived from a marine tunicate, is clinically effective in soft tissue sarcoma. The drug has shown a high selectivity for myxoid liposarcoma, characterized by the translocation t(12;16)(q13; p11) leading to the expression of FUS-CHOP fusion gene. Trab...

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Detalhes bibliográficos
Main Authors: Uboldi, Sarah, Calura, Enrica, Beltrame, Luca, Fuso Nerini, Ilaria, Marchini, Sergio, Cavalieri, Duccio, Erba, Eugenio, Chiorino, Giovanna, Ostano, Paola, D'Angelo, Daniela, D'Incalci, Maurizio, Romualdi, Chiara
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3327679/
https://ncbi.nlm.nih.gov/pubmed/22523595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035423
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