Endothelin-Converting Enzyme-1 Actions Determine Differential Trafficking and Signaling of Corticotropin-Releasing Factor Receptor 1 at High Agonist Concentrations

CRF receptor 1 (CRF(1)), a key neuroendocrine mediator of the stress response, has two known agonists corticotropin-releasing factor (CRF) and urocortin 1 (Ucn1). Here we report that endothelin-converting enzyme-1 (ECE-1) differentially degrades CRF and Ucn1; ECE-1 cleaves Ucn1, but not CRF, at crit...

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Detalhes bibliográficos
Main Authors: Hasdemir, Burcu, Mahajan, Shilpi, Bunnett, Nigel W., Liao, Min, Bhargava, Aditi
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2012
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3327357/
https://ncbi.nlm.nih.gov/pubmed/22322595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2011-1361
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