Increased signalling of EGFR and IGF1R, and deregulation of PTEN/PI3K/Akt pathway are related with trastuzumab resistance in HER2 breast carcinomas

BACKGROUND: Trastuzumab resistance hampers its well-known efficacy to control HER2-positive breast cancer. The involvement of PI3K/Akt pathway in this mechanism is still not definitively confirmed. METHODS: We selected 155 patients treated with trastuzumab after development of metastasis or as adjuv...

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Detalhes bibliográficos
Main Authors: Gallardo, A, Lerma, E, Escuin, D, Tibau, A, Muñoz, J, Ojeda, B, Barnadas, A, Adrover, E, Sánchez-Tejada, L, Giner, D, Ortiz-Martínez, F, Peiró, G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326683/
https://ncbi.nlm.nih.gov/pubmed/22454081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.85
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