Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor-negative breast cancer

BACKGROUND: We previously reported that sphingosine 1-phosphate receptor 4 (S1P(4)) is expressed and stimulates the ERK-1/2 pathway via a human epidermal growth factor receptor 2 (HER2)-dependent mechanism in oestrogen receptor-negative (ER(−)) MDA-MB-453 breast cancer cells. METHODS: Clinical relev...

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Hlavní autoři: Ohotski, J, Long, J S, Orange, C, Elsberger, B, Mallon, E, Doughty, J, Pyne, S, Pyne, N J, Edwards, J
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2012
Témata:
Molecular Diagnostics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326679/
https://ncbi.nlm.nih.gov/pubmed/22460268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.98
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