Engineering the First Chimeric Antibody in Targeting Intracellular PRL-3 Oncoprotein for Cancer Therapy in Mice

Antibodies are considered as ‘magic bullets’ because of their high specificity. It is believed that antibodies are too large to routinely enter the cytosol, thus antibody therapeutic approach has been limited to extracellular or secreted proteins expressed by cancer cells. However, many oncogenic pr...

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Bibliografiske detaljer
Main Authors: Guo, Ke, Tang, Jing Ping, Jie, Li, Al-Aidaroos, Abdul Qader O., Hong, Cheng William, Tan, Cheng Peow Bobby, Park, Jung Eun, Varghese, Leyon, Feng, Zhiwei, Zhou, Jianbiao, Chng, Wee Joo, Zeng, Qi
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2012
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326646/
https://ncbi.nlm.nih.gov/pubmed/22374986
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