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Sensitive kinase assay linked with phosphoproteomics for identifying direct kinase substrates

Our understanding of the molecular control of many disease pathologies requires the identification of direct substrates targeted by specific protein kinases. Here we describe an integrated proteomic strategy, termed kinase assay linked with phosphoproteomics, which combines a sensitive kinase reacti...

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Библиографические подробности
Главные авторы: Xue, Liang, Wang, Wen-Horng, Iliuk, Anton, Hu, Lianghai, Galan, Jacob A., Yu, Shuai, Hans, Michael, Geahlen, Robert L., Tao, W. Andy
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326509/
https://ncbi.nlm.nih.gov/pubmed/22451900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1119418109
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