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Resolving the complex role of enzyme conformational dynamics in catalytic function
Despite growing evidence suggesting the importance of enzyme conformational dynamics (ECD) in catalysis, a consensus on how precisely ECD influences the chemical step and reaction rates is yet to be reached. Here, we characterize ECD in Cyclophilin A, a well-studied peptidyl-prolyl cis-trans isomera...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3326486/ https://ncbi.nlm.nih.gov/pubmed/22451902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117060109 |
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