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Enzyme millisecond conformational dynamics do not catalyze the chemical step

The idea that enzymes catalyze reactions by dynamical coupling between the conformational motions and the chemical coordinates has recently attracted major experimental and theoretical interest. However, experimental studies have not directly established that the conformational motions transfer ener...

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Detalhes bibliográficos
Main Authors: Pisliakov, Andrei V., Cao, Jie, Kamerlin, Shina C. L., Warshel, Arieh
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2762662/
https://ncbi.nlm.nih.gov/pubmed/19805169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909150106
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