Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression

Once stimulated, the epidermal growth factor receptor (EGFR) undergoes self-phosphorylation, which, on the one hand, instigates signaling cascades, and on the other hand, recruits CBL ubiquitin ligases, which mark EGFRs for degradation. Using RNA interference screens, we identified a deubiquitinatin...

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Bibliografiske detaljer
Main Authors: Pareja, Fresia, Ferraro, Daniela Aleida, Rubin, Chanan, Cohen-Dvashi, Hadas, Zhang, Fan, Aulmann, Sebastian, Ben-Chetrit, Nir, Pines, Gur, Navon, Roy, Crosetto, Nicola, Köstler, Wolfgang, Carvalho, Silvia, Lavi, Sara, Schmitt, Fernando, Dikic, Ivan, Yakhini, Zohar, Sinn, Peter, Mills, Gordon B., Yarden, Yosef
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326441/
https://ncbi.nlm.nih.gov/pubmed/22179831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.587
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