Genetic variants of a BH3-only pro-apoptotic gene, PUMA, and risk of HPV16-associated squamous cell carcinoma of the head and neck

P53 up-regulated modulator of apoptosis (PUMA) is a critical factor in the intrinsic apoptotic pathway. Through PUMA-dependent mechanisms, human papillomavirus 16 (HPV16) oncoprotein may affect apoptosis by E6-mediated p53 degradation. To examine whether the PUMA variants modify the association betw...

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Hlavní autoři: Zhou, Ziyuan, Sturgis, Erich M., Liu, Zhensheng, Wang, Li-E, Wei, Qingyi, Li, Guojun
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326219/
https://ncbi.nlm.nih.gov/pubmed/22086558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.21838
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