Comparative Transcriptional Network Modeling of Three PPAR-α/γ Co-Agonists Reveals Distinct Metabolic Gene Signatures in Primary Human Hepatocytes

AIMS: To compare the molecular and biologic signatures of a balanced dual peroxisome proliferator-activated receptor (PPAR)-α/γ agonist, aleglitazar, with tesaglitazar (a dual PPAR-α/γ agonist) or a combination of pioglitazone (Pio; PPAR-γ agonist) and fenofibrate (Feno; PPAR-α agonist) in human hep...

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Detalhes bibliográficos
Main Authors: Deehan, Renée, Maerz-Weiss, Pia, Catlett, Natalie L., Steiner, Guido, Wong, Ben, Wright, Matthew B., Blander, Gil, Elliston, Keith O., Ladd, William, Bobadilla, Maria, Mizrahi, Jacques, Haefliger, Carolina, Edgar, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325914/
https://ncbi.nlm.nih.gov/pubmed/22514701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035012
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