Pure curcumin decreases the expression of WT1 by upregulation of miR-15a and miR-16-1 in leukemic cells

BACKGROUND: Pure curcumin has been reported to down-regulate the expression of WT1 in leukemic cells. However, the molecular mechanism underlying the down-regulation of WT1 by curcumin is not completely delineated. The purpose of this present study is to identify a new miRNA-mediated mechanism which...

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Main Authors: Gao, Shen-meng, Yang, Jun-jun, Chen, Chi-qi, Chen, Jun-jie, Ye, Li-ping, Wang, Lu-yao, Wu, Jian-bo, Xing, Chong-yun, Yu, Kang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325897/
https://ncbi.nlm.nih.gov/pubmed/22449094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-9966-31-27
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