Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair

Signaling pathways depend on regulatory protein-protein interactions; controlling these interactions in cells has important applications for reengineering biological functions. As many regulatory proteins are modular, considerable progress in engineering signaling circuits has been made by recombini...

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Hauptverfasser: Kapp, Gregory T., Liu, Sen, Stein, Amelie, Wong, Derek T., Reményi, Attila, Yeh, Brian J., Fraser, James S., Taunton, Jack, Lim, Wendell A., Kortemme, Tanja
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2012
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325720/
https://ncbi.nlm.nih.gov/pubmed/22403064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114487109
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