Cells test substrate rigidity by local contractions on submicrometer pillars

Cell growth and differentiation are critically dependent upon matrix rigidity, yet many aspects of the cellular rigidity-sensing mechanism are not understood. Here, we analyze matrix forces after initial cell–matrix contact, when early rigidity-sensing events occur, using a series of elastomeric pil...

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Bibliographic Details
Main Authors: Ghassemi, Saba, Meacci, Giovanni, Liu, Shuaimin, Gondarenko, Alexander A., Mathur, Anurag, Roca-Cusachs, Pere, Sheetz, Michael P., Hone, James
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325713/
https://ncbi.nlm.nih.gov/pubmed/22431603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1119886109
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