Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior

Fifty years ago, increased whole-blood serotonin levels, or hyperserotonemia, first linked disrupted 5-HT homeostasis to Autism Spectrum Disorders (ASDs). The 5-HT transporter (SERT) gene (SLC6A4) has been associated with whole blood 5-HT levels and ASD susceptibility. Previously, we identified mult...

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Detalhes bibliográficos
Main Authors: Veenstra-VanderWeele, Jeremy, Muller, Christopher L., Iwamoto, Hideki, Sauer, Jennifer E., Owens, W. Anthony, Shah, Charisma R., Cohen, Jordan, Mannangatti, Padmanabhan, Jessen, Tammy, Thompson, Brent J., Ye, Ran, Kerr, Travis M., Carneiro, Ana M., Crawley, Jacqueline N., Sanders-Bush, Elaine, McMahon, Douglas G., Ramamoorthy, Sammanda, Daws, Lynette C., Sutcliffe, James S., Blakely, Randy D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325657/
https://ncbi.nlm.nih.gov/pubmed/22431635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112345109
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