Solution structure analysis of the HPV16 E6 oncoprotein reveals a self-association mechanism required for E6-mediated degradation of p53

The viral oncoprotein E6 is an essential factor for cervical cancers induced by “high-risk” mucosal HPV. Among other oncogenic activities, E6 recruits the ubiquitin ligase E6AP to promote the ubiquitination and subsequent proteasomal degradation of p53. E6 is prone to self-association, which long pr...

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Bibliografiske detaljer
Main Authors: Zanier, Katia, Sidi, Abdellahi ould M’hamed ould, Boulade-Ladame, Charlotte, Rybin, Vladimir, Chappelle, Anne, Atkinson, Andrew, Kieffer, Bruno, Travé, Gilles
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325491/
https://ncbi.nlm.nih.gov/pubmed/22483108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.02.001
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