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T-antigen binding to site I facilitates initiation of SV40 DNA replication but does not affect bidirectionality.
SV40 origin auxiliary sequence 1 (aux-1) encompasses T-antigen (T-ag) binding site I and facilitates origin core (ori-core) activity in whole cells or cell extracts. Aux-1 activity depended completely upon its sequence, orientation and spacing relative to ori-core. Aux-1 activity was lost either by...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
1991
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| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC332519/ https://ncbi.nlm.nih.gov/pubmed/1662806 |
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