Mutations in the phosphorylation sites of simian virus 40 (SV40) T antigen alter its origin DNA-binding specificity for sites I or II and affect SV40 DNA replication activity.

A series of mutants of simian virus 40 was constructed by oligonucleotide-directed mutagenesis to study the role of phosphorylation in the functions of large T antigen. Each of the previously mapped phosphorylated serine and threonine residues in large T antigen was replaced by an alanine or cystein...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Schneider, J, Fanning, E
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 1988
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC253187/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3357207/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.62.5.1598-1605.1988
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