Mutation of the cyclin-dependent kinase phosphorylation site in simian virus 40 (SV40) large T antigen specifically blocks SV40 origin DNA unwinding.

A mutant simian virus 40 (SV40) large tumor (T) antigen bearing alanine instead of threonine at residue 124 (T124A) failed to replicate SV40 DNA in infected monkey cells (J. Schneider and E. Fanning, J. Virol. 62:1598-1605, 1988). We investigated the biochemical properties of T124A T antigen in grea...

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Vydáno v:	J Virol
Hlavní autoři:	Moarefi, I F, Small, D, Gilbert, I, Höpfner, M, Randall, S K, Schneider, C, Russo, A A, Ramsperger, U, Arthur, A K, Stahl, H
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1993
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC237887/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8392624/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.67.8.4992-5002.1993
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Mutation of the cyclin-dependent kinase phosphorylation site in simian virus 40 (SV40) large T antigen specifically blocks SV40 origin DNA unwinding.

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