Mutation of the cyclin-dependent kinase phosphorylation site in simian virus 40 (SV40) large T antigen specifically blocks SV40 origin DNA unwinding.

A mutant simian virus 40 (SV40) large tumor (T) antigen bearing alanine instead of threonine at residue 124 (T124A) failed to replicate SV40 DNA in infected monkey cells (J. Schneider and E. Fanning, J. Virol. 62:1598-1605, 1988). We investigated the biochemical properties of T124A T antigen in grea...

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Dettagli Bibliografici
Autori principali: Moarefi, I F, Small, D, Gilbert, I, Höpfner, M, Randall, S K, Schneider, C, Russo, A A, Ramsperger, U, Arthur, A K, Stahl, H
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1993
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC237887/
https://ncbi.nlm.nih.gov/pubmed/8392624
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