Mutation of the cyclin-dependent kinase phosphorylation site in simian virus 40 (SV40) large T antigen specifically blocks SV40 origin DNA unwinding.

A mutant simian virus 40 (SV40) large tumor (T) antigen bearing alanine instead of threonine at residue 124 (T124A) failed to replicate SV40 DNA in infected monkey cells (J. Schneider and E. Fanning, J. Virol. 62:1598-1605, 1988). We investigated the biochemical properties of T124A T antigen in grea...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Moarefi, I F, Small, D, Gilbert, I, Höpfner, M, Randall, S K, Schneider, C, Russo, A A, Ramsperger, U, Arthur, A K, Stahl, H
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC237887/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8392624/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.67.8.4992-5002.1993
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